CHEMISTRY COMMUNICATION

Neutral dimeric copper–sparfloxacin conjugate having butterfly motif with antiproliferative effects against hormone independent BT20 breast cancer cell line

according to scientists ;Dipti Shingnapurkar^a, Ray Butcher^b, Zahra Afrasiabi^{c, 1}, Ekkhard Sinn^c, Fakhara Ahmed^d, Fazlul Sarkar^d and Subhash Padhye^{a, ,}

References and further reading may be available for this article. To view references and further reading you must purchase this article.

^aDepartment of Chemistry, University of Pune, Ganeshkhind Road, Pune 411007, India

^bDepartment of Chemistry, Howard University, Washington, DC 20009, USA

^cDepartment of Chemistry, University of Missouri-Rolla, Rolla 65401, USA

^dDepartment of Pathology, Karmanos Cancer Institute at Wayne State University School of Medicine, Detroit, Michigan MI 48201, USA

Received 20 September 2006;

Abstract

A neutral dimeric copper conjugate of sparfloxacin and its phenanthroline adduct show considerable enhancement in their antiproliferative activities against hormone independent BT20 breast cancer cells.

Graphical abstract

A neutral dimeric copper conjugate of sparfloxacin, having butterfly scaffold shows 10-fold enhancement in its antiproliferative activity against hormone independent BT20 breast cancer cells.